Memé (Emanuele) Di Costanzo is an estate agent who has lost everything, including money, and lives with his grandmother Nana and his dog Piccolo. His life often relies on the financial help of his lover, Eliana. Memé, looking for a solution to his financial difficulties, decides to take advantage of the naivety of Isotta, a pharmacist who has a crush on him. He marries her, although his real intention is to use her for his own financial well-being.
Isolde, at first unaware of Nana and Piccolo's presence, tries to bear the situation patiently. However, as time passes, the situation becomes untenable. Nana, Memé's grandmother, falls ill and is locked up in an old people's home.
After a few weeks, Memé feels a deep sense of guilt and abandons Isolde to take care of his grandmother and his dog Piccolo. When it seemed that the problems with Isolde were over, Nana suddenly dies.
Without financial means and tormented by misery, Memé even thinks of killing Piccolo, but in the end he cannot bring himself to do such an evil deed. He decides to leave on a ferry, but during the preparations he is involved in a car accident that slightly injures him, causing him to faint.
He thinks he has also lost Piccolo forever, but seven months after the tragic accident, his faithful dog returns safe and sound. Memé then returns to live with Isotta and her troublesome family, as he is without means and cannot do otherwise.